The event which most historians of science call the scientific revolution can be dated roughly as having begun in 1543, the year in which Nicolaus Copernicus published his De revolutionibus orbium coelestium (On the Revolutions of the Heavenly Spheres) and Andreas Vesalius published his De humani corporis fabrica (On the Fabric of the Human body). As with many historical demarcations, historians of science disagree about its boundaries, some seeing elements contributing to the revolution as early as the 11th century, and finding its last stages in chemistry and biology in the 18th and 19th centuries. There is general agreement, however, that the intervening period saw a fundamental transformation in scientific ideas in physics, astronomy and biology, in institutions supporting scientific investigation, and in the more widely held picture of the universe.