Pepperoni is a spicy Italian-American variety of dry salami usually made of goat, pork, beef and sometimes fish.citation needed] Pepperoni is often used on pizza, and sometimes it is used on sub sandwiches. Pepperoni is a descendant of the spicy salamis of Southern Italy, such as salsiccia Napoletana piccante, a spicy dry sausage from Naples. Pepperoni is frequently used as a pizza topping in American-style pizzerias. It is the most popular pizza topping in North America. citation needed]