Annihilation is a Marvel Comics 2006 crossover event highlighting several relatively under-used outer space-related characters in the Marvel Universe.
Annihilation started with a 48-page one-shot issue entitled Annihilation: Prologue which was released on March 15, 2006 and then followed by four 4-issue limited series: Annihilation: Silver Surfer (April 1 2006), Annihilation: Super-Skrull (April 12 2006), Annihilation: Nova (April 19 2006), and Annihilation: Ronan (April 26 2006). The event concludes with a 6-issue miniseries entitled Annihilation, bringing the four stories together. The mini-series Drax the Destroyer: Earth Fall (September 28 2005) was a prelude to the event.