Synergy (from the Greek synergos, συνεργός meaning working together, circa 1660) refers to the phenomenon in which two or more discrete influences or agents acting together create an effect greater than that predicted by knowing only the separate effects of the individual agents. It is originally a scientific term. Often (but not always, see Toxicologic synergy, below) the prediction is the sum of the effects each is able to create independently. The opposite of synergy is antagonism, the phenomenon where two agents in combination have an overall effect which is less than that predicted from their individual effects. Synergism stems from the 1657 theological doctrine that human will cooperates with the Divine Grace in regeneration. The term began to be used in the broader, non-theological, sense by 1925. Synergy can also mean: