Syndrome is the villain name of Buddy Pine (calls himself Incredi-Boy earlier in the film), is a fictional character, the main supervillain featured in the film The Incredibles, (produced by Pixar and Disney, first released on November 5th, 2004), the short film Jack-Jack Attack, and the Disney on Ice play, Disney Presents Pixar's The Incredibles in a Magic Kingdom Adventure (albeit as a "robot copy"). Because of events in the movie, he is widely considered to be the archenemy of the Incredible Family; he is even stated as such in the guidebook for the on-ice play. Wizard Magazine rated him the 64th greatest villain of all time.
Syndrome is a tall (6 feet, 1 inch not including the height of his hairstyle), barrel-chested (185 lb (84 kg)) man whose red hair extends straight up in a manner reminiscent of flames, apparently because of the power that flows from his evil mind (according to a Dorling Kindersley guidebook). He is voiced by Jason Lee, who - perhaps not coincidentally - had previously portrayed a comic book superhero artist in Chasing Amy and a superhero-obsessed comic book (Brodie Bruce) collector in Mallrats. There is also a scene in The Incredibles where Mr. Incredible is trying to remember his name and calls him Brodie. Both films were written and directed by comics fan Kevin Smith.
Syndrome is supposedly "not a super", but he demonstrates exceptional ingenuity, technical know-how, planning, and perception far beyond the science of his time. This is similar to Marvel Comics' Doctor Doom and DC Comics' Lex Luthor.